P.D. Fransquet, P. Lacaze, R. Saffery, R.C. Shah, R. Vryer, A. Murray, R.L. Woods and J. Ryan* Pages 443 - 451 ( 9 )
<P>Background: There is strong evidence that epigenetic age acceleration is associated with increased risk of later-life diseases and all-cause mortality. However, there is currently limited evidence that suggests accelerated epigenetic age is associated with dementia risk. </P><P> Objective: This study aims to clarify whether epigenetic biomarkers of accelerated aging can predict dementia risk, which is an important consideration as aging is the greatest risk factor for the disease. </P><P> Methods: DNA methylation was measured in peripheral blood samples provided by 160 participants from the ASPirin in Reducing Events in the Elderly study, including 73 pre-symptomatic dementia cases and 87 controls matched for age, sex, and smoking and education status. Epigenetic age was calculated using Horvath, Hannum, GrimAge and PhenoAge DNA methylation clocks, and age acceleration (the disparity between chronological age and epigenetic age) was determined. </P><P> Results: There was no difference in age acceleration between dementia cases and controls. In males, only Hannum’s intrinsic epigenetic age acceleration was increased in pre-symptomatic dementia cases compared to controls (Δ +1.8 years, p = 0.03). </P><P> Conclusion: These findings provide no strong evidence that accelerated epigenetic aging measured in peripheral blood can predict dementia risk.</P>
Accelerated Aging, dementia, DNA methylation, epigenetic clock, grimAge, hannum, horvath, phenoAge.
School of Public Health and Preventive Medicine, Monash University, Melbourne, 3004, Victoria, School of Public Health and Preventive Medicine, Monash University, Melbourne, 3004, Victoria, Murdoch Children’s Research Institute, Department of Paediatrics, The University of Melbourne, Parkville, 3052 Victoria, Department of Family Medicine and Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL 60612, Murdoch Children’s Research Institute, Department of Paediatrics, The University of Melbourne, Parkville, 3052 Victoria, Berman Center for Outcomes and Clinical Research, Hennepin Healthcare Research Institute, Hennepin Healthcare, Division of Geriatrics, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, School of Public Health and Preventive Medicine, Monash University, Melbourne, 3004, Victoria, School of Public Health and Preventive Medicine, Monash University, Melbourne, 3004, Victoria