Lucia M. Balsa, Enrique J. Baran and Ignacio E. León * Pages 510 - 557 ( 48 )
<p>Copper is an essential element for most aerobic organisms, with an important function as a structural and catalytic cofactor, and in consequence, it is implicated in several biological actions. <p> The relevant aspects of chemistry and biochemistry and the importance of copper compounds in medicine give us a comprehensive knowledge of the multifaceted applications of copper in physiology and physiopathology. <p> In this review, we present an outline of the chemistry, and the antitumor properties of copper complexes on breast, colon, and lung cancer cells focus on the role of copper in cancer, the relationship between structure-activity, molecular targets, and the study of the mechanism of action involved in its anticancer activity. This overview is expected to contribute to understanding the design, synthesis, and uses of copper complexes as antitumor agents in the most common cancers.</p>
Copper, cancer, mechanism of action, SAR, cisplatin, tumors.
Centro de Química Inorgánica (CEQUINOR; UNLP-CONICET), Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Bv.120 N 1465, 1900 La Plata, Centro de Química Inorgánica (CEQUINOR; UNLP-CONICET), Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Bv.120 N 1465, 1900 La Plata, Centro de Química Inorgánica (CEQUINOR; UNLP-CONICET), Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Bv.120 N 1465, 1900 La Plata