Submit Manuscript  

Article Details

Dual Inhibition and Monitoring of Beta-Amyloid Fibrillation by a Luminescent Iridium(III) Complex

[ Vol. 12 , Issue. 5 ]


Chun-Yuen Wong, Lai-Hon Chung, Lihua Lu, Modi Wang, Bingyong He, Li-Juan Liu, Chung-Hang Leung and Dik-Lung Ma   Pages 439 - 444 ( 6 )


In this study, we report the synthesis and application of the novel cyclometallated luminescent Ir(III) complex 1 bearing the C^C^C ligand as a probe and inhibitor of Aβ fibrillation. We envisage that this kinetically-inert Ir(III) complex may be potentially developed as a dual-purpose probe and inhibitor of Aβ aggregation for Alzheimer’s disease diagnosis and treatment.


Amyloid, aggregation, Alzheimer's, luminescent probe, iridium.


Department of Biology and Chemistry, City University of Hong Kong, Kowloon, Hong Kong, China.

Read Full-Text article