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Ceramide and Sphingosine-1-Phosphate in Cell Death Pathways : Relevance to the Pathogenesis of Alzheimer's Disease

[ Vol. 13 , Issue. 11 ]

Author(s):

Sankha Shubhra Chakrabarti, Aritri Bir, Jit Poddar, Maitrayee Sinha, Anirban Ganguly and Sasanka Chakrabarti   Pages 1232 - 1248 ( 17 )

Abstract:


The metabolic turnover of sphingolipids produces several signaling molecules that profoundly affect the proliferation, differentiation and death of cells. In particular, an enormous body of information is available that defines the varied role of ceramide and sphingosine-1-phosphate in cell death and survival. This review specifically examines the role of ceramide and sphingosine-1- phosphate in triggering neuronal death in Alzheimer's disease by analyzing the data from post-mortem studies and experimental research. There is compelling evidence that ceramide plays a key role in the neurodegeneration and amyloidogenesis occurring in the brain in Alzheimer's disease. Further, it appears that ceramide and amyloid beta protein orchestrate an attack on mitochondria to set in the pathways of cell death. However, the complexity of metabolic and signaling pathways of sphingolipid derivatives precludes an immediate identification of effective drug targets for the therapy of Alzheimer's disease.

Keywords:

Sphingomyelin, Ceramide, Sphingosine-1-phosphate, Mitochondria, Amyloid beta protein, Apoptosis, Necroptosis, Alzheimer's disease.

Affiliation:

ICARE Institute of Medical Sciences and Research – Biochemistry, Haldia, India.



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