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Primary and Secondary Prevention Trials in Alzheimer Disease: Looking Back, Moving Forward

[ Vol. 14 , Issue. 4 ]


David Hsu and Gad A. Marshall   Pages 426 - 440 ( 15 )


The field of Alzheimer disease (AD) prevention has been a culmination of basic science, clinical, and translational research. In the past three years since the new 2011 AD diagnostic guidelines, large-scale collaborative efforts have embarked on new clinical trials with the hope of someday preventing AD. This review will shed light on the historical and scientific contexts in which these trials were based on, as well as discuss potential challenges these trials may face in the coming years. Primary preventive measures, such as lifestyle, multidomain, medication, and supplemental interventions, will be analyzed. Secondary prevention as represented by disease-modifying interventions, such as antiamyloid therapy and pioglitazone, will also be reviewed. Finally, hypotheses on future directions for AD prevention trials will be proposed.


Alzheimer disease, neuropsychological, pathophysiology, anxiety, hypertension.


Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115,, Alzheimer Research and Treatment, Brigham and Women's Hospital, 60 Fenwood Road, 9016P, Boston, MA 02115

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