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Commonalities in Biological Pathways, Genetics, and Cellular Mechanism between Alzheimer Disease and Other Neurodegenerative Diseases: An In Silico-Updated Overview

[ Vol. 14 , Issue. 11 ]

Author(s):

Khurshid Ahmad, Mohammad Hassan Baig*, Gohar Mushtaq, Mohammad Amjad Kamal, Nigel H. Greig and Inho Choi*   Pages 1190 - 1197 ( 8 )

Abstract:


Background: Alzheimer's disease (AD) is the most common and well-studied neurodegenerative disease (ND). Biological pathways, pathophysiology and genetics of AD show commonalities with other NDs viz. Parkinson's disease (PD), Amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), Prion disease and Dentatorubral-pallidoluysian atrophy (DRPLA). Many of the NDs, sharing the common features and molecular mechanisms suggest that pathology may be directly comparable and be implicated in disease prevention and development of highly effective therapies.

Method: In this review, a brief description of pathophysiology, clinical symptoms and available treatment of various NDs have been explored with special emphasis on AD. Commonalities in these fatal NDs provide support for therapeutic advancements and enhance the understanding of disease manifestation.

Conclusion: The studies concentrating on the commonalities in biological pathways, cellular mechanisms and genetics may provide the scope to researchers to identify few novel common target(s) for disease prevention and development of effective common drugs for multi-neurodegenerative diseases.

Keywords:

Neurodegenerative diseases, Alzheimer disease, Parkinson's disease, Huntington's disease, Amyotrophic lateral sclerosis, biological pathways.

Affiliation:

Department of Medical Biotechnology, Yeungnam University, Gyeongsan, Department of Medical Biotechnology, Yeungnam University, 280 Daehak-ro, Gyeongsan, Gyeongbuk 712-749, Department of Biochemistry, College of Science, King Abdulaziz University, Jeddah 21589, King Fahd Medical Research Centre, King Abdulaziz University, P.O. Box 80216, Jeddah 21589, Drug Design & Development Section, Translational Gerontology Branch, Intramural Research Program, National, Institute on Aging, National Institutes of Health, Biomedical Research Center, 251 Bayview Boulevard, Baltimore, MD 21224, Department of Medical Biotechnology, Yeungnam University, 280 Daehak-ro, Gyeongsan, Gyeongbuk 712-749



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