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Prevalence of Frailty in Mild to Moderate Alzheimer's Disease: A Systematic Review and Meta-analysis

[ Vol. 14 , Issue. 12 ]

Author(s):

Gotaro Kojima*, Ann Liljas, Steve Iliffe and Kate Walters   Pages 1256 - 1263 ( 8 )

Abstract:


Background: Frailty is a state of increased vulnerability to poor resolution of homeostasis as a consequence of age-related decreased physiological reserves. Although physical frailty and cognitive impairment have been shown to be associated, evidence on the prevalence of frailty in Alzheimer's disease is scarce.

Objective: To conduct a systematic review on the prevalence of frailty and to combine the data to synthesize the pooled prevalence of physical frailty among patients with Alzheimer's disease.

Method: Five electronic databases (Embase, MEDLINE, CINAHL Plus, PsycINFO, and the Cochrane Library) were searched for studies providing cross-sectional data on physical frailty among patients with Alzheimer's disease published from 2000 to January 2016.

Results: Of 2,564 studies identified through the systematic review, five studies incorporating 534 patients with Alzheimer's disease were included for the meta-analysis. The prevalence of frailty varied with a wide range from 11.1% to 50.0% and the pooled prevalence was 31.9% (five studies, 95% confidence interval (CI)=15.7%-48.5%). The high degree of heterogeneity was observed in all analyses. A borderline publication bias was detected.

Conclusion: The current study showed that frailty is highly prevalent in older patients with Alzheimer's disease in the community with the pooled prevalence of 31.9%. The true prevalence may be much higher given that end-stage patients may not be included. This information is important for clinicians and researchers.

Keywords:

Frailty, Alzheimer's disease, dementia, prevalence, systematic review, meta-analysis.

Affiliation:

Department of Primary Care and Population Health, University College London (Royal Free Campus) Rowland Hill Street, London, NW3 2PF, Department of Primary Care and Population Health, University College London, London, Department of Primary Care and Population Health, University College London, London, Department of Primary Care and Population Health, University College London, London



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