Javed Ahmad, Sohail Akhter*, Md. Rizwanullah, Mohammad Ahmed Khan, Lucie Pigeon, Richard T. Addo, Nigel H. Greig, Patrick Midoux, Chantal Pichon and Mohammad Amjad Kamal Pages 1164 - 1181 ( 18 )
Background: Alzheimer's disease (AD), a cognitive dysfunction/dementia state amongst the elders is characterized by irreversible neurodegeneration due to varied pathophysiology. Up till now, anti-AD drugs having different pharmacology have been developed and used in clinic. Yet, these medications are not curative and only lowering the AD associated symptoms. Improvement in treatment outcome required drug targeting across the blood-brain barrier (BBB) to the central nervous system (CNS) in optimal therapeutic concentration. Nanotechnology based diagnostic tools, drug carriers and theranostics offer highly sensitive molecular detection, effective drug targeting and their combination. Over the past decade, significant works have been done in this area and we have seen very remarkable outocome in AD therapy. Various nanoparticles from organic and inorganic nanomaterial category have successfully been investigated against AD.
Conclusion: This paper discussed the role of nanoparticles in early detection of AD, effective drug targeting to brain and theranostic (diagnosis and therapy) approaches in AD's management.
Alzheimer's disease, blood brain barrier, diagnosis, theranostic, nanoparticles, nanomedicines.
Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Raebareli, UP- 229010, Centre de Biophysique Moléculaire, (CBM)-CNRS/ University of Orléans, UPR4301, Rue Charles Sadron, 45071, Orléans Cedex 2, Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi-110062, Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, New Delhi-110062, Nucleic acids transfer by non viral methods, Centre de Biophysique Moleculaire, CNRS UPR4301, Orleans, Union University, School of Pharmacy Room 149 Providence Hall, 1050 Union University Drive, Jackson, TN 38305, Drug Design & Development Section, Translational Gerontology Branch, Intramural Research Program, National, Institute on Aging, National Institutes of Health, Biomedical Research Center, 251 Bayview Boulevard, Baltimore, MD 21224, Nucleic acids transfer by non viral methods, Centre de Biophysique Moleculaire, CNRS UPR4301, Orleans, Nucleic acids transfer by non viral methods, Centre de Biophysique Moleculaire, CNRS UPR4301, Orleans, Novel Global Community Educational Foundation