Submit Manuscript  

Article Details


miRNAs in Alzheimer Disease – A Therapeutic Perspective

[ Vol. 14 , Issue. 11 ]

Author(s):

Priya Gupta, Surajit Bhattacharjee, Ashish Ranjan Sharma, Garima Sharma, Sang-Soo Lee* and Chiranjib Chakraborty*   Pages 1198 - 1206 ( 9 )

Abstract:


Background: Alzheimer's disease is a neurodegenerative disorder which generally affects people who are more than 60 years of age. The disease is clinically characterised by dementia, loss of cognitive functions and massive neurodegeneration. The presence of neurofibrilary tangles and amyloid plaques in the hippocampal region of the brain are the hallmarks of the disease. Current therapeutic approaches for the treatment of Alzheimer's disease are symptomatic and disease modifying, none of which provide any permanent solution or cure for the disease. Dysregulation of miRNAs is one of the major causes of neurodegeneration.

Conclusion: In the present review, the roles of different miRNAs such as miR-9, miR-107, miR-29, miR-34, miR-181, miR-106, miR-146a, miR132, miR124a, miR153 has been discussed in detail in the pathogenesis of various neurodegenerative diseases with special focus on AD. The probability of miRNAs as an alternative and more sensitive approach for detection and management of the AD has also been discussed.

Keywords:

Alzheimer's disease, neurodegeneration, miRNAs, therapeutics, dementia, neural plaques.

Affiliation:

Department of Molecular Biology & Bioinformatics, Tripura University (A Central University), Suryamaninagar, Tripura-799022, Department of Molecular Biology & Bioinformatics, Tripura University (A Central University), Suryamaninagar, Tripura-799022, Institute for Skeletal Aging & Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon 200704, Institute for Skeletal Aging & Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon 200704, Institute for Skeletal Aging & Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon 200704, Department of Bioinformatics, Galgotias University, Uttar Pradesh



Read Full-Text article