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Phenolic Acids Exert Anticholinesterase and Cognition-Improving Effects

[ Vol. 15 , Issue. 6 ]

Author(s):

Dominik Szwajgier*, Ewa Baranowska-Wojcik and Kamila Borowiec   Pages 531 - 543 ( 13 )

Abstract:


Numerous authors have provided evidence regarding the beneficial effects of phenolic acids and their derivatives against Alzheimer's disease (AD). In this review, the role of phenolic acids as inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) is discussed, including the structure-activity relationship. In addition, the inhibitory effect of phenolic acids on the formation of amyloid β-peptide (Aβ) fibrils is presented. We also cover the in vitro, ex vivo, and in vivo studies concerning the prevention and treatment of the cognitive enhancement.

Keywords:

Alzheimer's disease, amyloid β-peptide, cinnamic acid, benzoic acid, acetylcholinesterase, butyrylcholinesterase, cognition.

Affiliation:

Department of Biotechnology, University of Life Sciences in Lublin, Human Nutrition and the Science of Food Commodities, Skromna Street 8, Lublin 20-950, Department of Biotechnology, University of Life Sciences in Lublin, Human Nutrition and the Science of Food Commodities, Skromna Street 8, Lublin 20-950, Department of Biotechnology, University of Life Sciences in Lublin, Human Nutrition and the Science of Food Commodities, Skromna Street 8, Lublin 20-950



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