Ignazio Vecchio, Cristina Tornali, Giulia Malaguarnera, Nicola Luigi Bragazzi and Michele Malaguarnera* Pages 959 - 963 ( 5 )
The progressive supranuclear palsy is a progressive neurodegenerative disease characterized by Parkinsonism, oculomotor abnormalities, early postural instability and cognitive impairment. Neurodegeneration in PSP is associated with tau protein, but the mechanisms by which tau abnormalities lead to cell dysfunction and death are not well understood.
Neuro-behavioural problems related to the fear and loss of autonomy can determinate many bioethical implications. Careful planning involving patients’ families, academic and industry researchers were necessary to ensure improvement in quality of life.
Progressive supranuclear palsy, tonopathy, movement disorders, bioethics, clinical ethics, cognitive disease.
Department of Clinical and Experimental Medicine, University of Catania, 95100 Catania, Department of Biomedical and Biotechnological Sciences, University of Catania, 95100 Catania, Research Center , Section of History of Medicine and Ethics, Department of Health Sciences (DISSAL), University of Genoa, 16132 Genoa, Research Center