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Identify Compounds' Target Against Alzheimer's Disease Based on In-Silico Approach

[ Vol. 16 , Issue. 3 ]

Author(s):

Yan Hu, Guangya Zhou, Chi Zhang, Mengying Zhang, Qin Chen*, Linfeng Zheng* and Bing Niu*   Pages 193 - 208 ( 16 )

Abstract:


Background: Alzheimer's disease swept every corner of the globe and the number of patients worldwide has been rising. At present, there are as many as 30 million people with Alzheimer's disease in the world, and it is expected to exceed 80 million people by 2050. Consequently, the study of Alzheimer’s drugs has become one of the most popular medical topics.

Methods: In this study, in order to build a predicting model for Alzheimer’s drugs and targets, the attribute discriminators CfsSubsetEval, ConsistencySubsetEval and FilteredSubsetEval are combined with search methods such as BestFirst, GeneticSearch and Greedystepwise to filter the molecular descriptors. Then the machine learning algorithms such as BayesNet, SVM, KNN and C4.5 are used to construct the 2D-Structure Activity Relationship(2D-SAR) model. Its modeling results are utilized for Receiver Operating Characteristic curve(ROC) analysis.

Results: The prediction rates of correctness using Randomforest for AChE, BChE, MAO-B, BACE1, Tau protein and Non-inhibitor are 77.0%, 79.1%, 100.0%, 94.2%, 93.2% and 94.9%, respectively, which are overwhelming as compared to those of BayesNet, BP, SVM, KNN, AdaBoost and C4.5.

Conclusion: In this paper, we conclude that Random Forest is the best learner model for the prediction of Alzheimer’s drugs and targets. Besides, we set up an online server to predict whether a small molecule is the inhibitor of Alzheimer's target at http://47.106.158.30:8080/AD/. Furthermore, it can distinguish the target protein of a small molecule.

Keywords:

Machine learning (ML), Alzheimer's disease, BayesNet, BP neural network (BP), support vector machine (SVM), K nearest-neighbors (KNN), AdaBoost, random forest (RF), C4.5, web server.

Affiliation:

School of Life Sciences, Shanghai University, Shanghai 200444, School of Life Sciences, Shanghai University, Shanghai 200444, Huaxia Eye Hospital of Foshan, Huaxia Eye Hospital Group, Foshan, Guangdong, School of Life Sciences, Shanghai University, Shanghai 200444, School of Life Sciences, Shanghai University, Shanghai 200444, Department of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 200080, School of Life Sciences, Shanghai University, Shanghai 200444



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