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Neuroinflammation in Alzheimer’s Disease: Microglia, Molecular Participants and Therapeutic Choices

[ Vol. 16 , Issue. 7 ]

Author(s):

Haijun Wang, Yin Shen, Haoyu Chuang, Chengdi Chiu, Youfan Ye and Lei Zhao*   Pages 659 - 674 ( 16 )

Abstract:


Alzheimer’s disease is the world’s most common dementing illness. It is pathologically characterized by β-amyloid accumulation, extracellular senile plaques and intracellular neurofibrillary tangles formation, and neuronal necrosis and apoptosis. Neuroinflammation has been widely recognized as a crucial process that participates in AD pathogenesis. In this review, we briefly summarized the involvement of microglia in the neuroinflammatory process of Alzheimer’s disease. Its roles in the AD onset and progression are also discussed. Numerous molecules, including interleukins, tumor necrosis factor alpha, chemokines, inflammasomes, participate in the complex process of AD-related neuroinflammation and they are selectively discussed in this review. In the end of this paper from an inflammation- related perspective, we discussed some potential therapeutic choices.

Keywords:

Alzheimer's disease, neuroinflammation, microglia, beta-amyloid, dementia, chemokinases.

Affiliation:

Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, School of Medicine, China Medical University, Taichung, School of Medicine, China Medical University, Taichung, Department of Ophthalmology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, Department of Infectious Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei



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