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Assessment of persistent, bioaccumulative and toxic organic environmental pollutants in liver and adipose tissue of Alzheimer’s disease patients and age- matched controls

Author(s):

Bhagyashree Manivannan*, Manivannan Yegambaram*, Samuel Supowit, Thomas G. Beach and Rolf U. Halden  

Abstract:


Background: Lifetime exposure to environmental (neuro) toxicants may contribute to the pathogenesis of Alzheimer’s disease (AD). Since many contaminants do not cross the blood-brain barrier, brain tissue alone cannot serve to assess the spectrum of environmental exposures.

Methods: We used liquid and gas chromatography tandem mass spectrometry to monitor, in post-mortem liver and adipose tissues of AD patients and age-matched controls, the occurrence and concentrations of 11 environmental contaminants.

Results: Seven toxicants were detected at 100% frequency: p,p'- DDE, dieldrin, triclosan, methylparaben, bisphenol A, fipronil and tetrabromobisphenol A (TBBPA). Intra-individual, tissue-dependent differences were detected for triclosan, methylparaben, fipronil and TBBPA. High concentrations of p,p’-DDE and dieldrin were observed in adipose tissue when compared to liver values for both AD cases and controls.

Conclusion: This study provides vital data on organ-specific human body burdens for select analytes and demonstrates the feasibility of analyzing small sample quantities for toxicants suspected to constitute AD risk factors.

Keywords:

Alzheimer`s disease; environmental (neuro) toxicants; pollutants; contaminants; liquid and gas chromatography tandem mass spectrometry; liver; adipose tissue

Affiliation:

Biodesign Center for Environmental Health Engineering, Arizona State University, Tempe, AZ, Biodesign Center for Environmental Health Engineering, Arizona State University, Tempe, AZ, Biodesign Center for Environmental Health Engineering, Arizona State University, Tempe, AZ, Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, AZ, Biodesign Center for Environmental Health Engineering, Arizona State University, Tempe, AZ



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