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Tau PET Distributional Pattern in AD Patients with Visuospatial Dysfunction

[ Vol. 16 , Issue. 11 ]

Author(s):

Xi Sun, Binbin Nie, Shujun Zhao, Qian Chen, Panlong Li, Tianhao Zhang, Tingting Pan, Ting Feng, Luying Wang, Xiaolong Yin, Wei Zhang, Shilun Zhao, Baoci Shan, Hua Liu*, Shengxiang Liang*, Lin Ai* and Guihong Wang*   Pages 1055 - 1062 ( 8 )

Abstract:


Background: Visuospatial dysfunction is one predominant symptom in many atypical Alzheimer’s disease (AD) patients, however, until now its neural correlates still remain unclear. For the accumulation of intracellular hyperphosphorylated tau proteins is a major pathogenic factor in neurodegeneration of AD, the distributional pattern of tau could highlight the affected brain regions associated with specific cognitive deficits.

Objective: We investigated the brain regions particularly affected by tau accumulation in patients with visuospatial dysfunction to explore its neural correlates.

Methods: Using 18F-AV-1451 tau positron emission tomography (PET), voxel-wise two-sample t-tests were performed between AD patients with obvious visuospatial dysfunction (VS-AD) and cognitively normal subjects, AD patients with little-to-no visuospatial dysfunction (non VS-AD) and cognitively normal subjects, respectively.

Results: Results showed increased tau accumulations mainly located in occipitoparietal cortex, posterior cingulate cortex, precuneus, inferior and medial temporal cortex in VS-AD patients, while increased tau accumulations mainly occurred in the inferior and medial temporal cortex in non VS-AD patients.

Conclusion: These findings suggested that occipitoparietal cortex, posterior cingulate cortex and precuneus, which were particularly affected by increased tau accumulation in VS-AD patients, may associate with visuospatial dysfunction of AD.

Keywords:

Alzheimer's disease, visuospatial dysfunction, tau PET, hyperphosphorylated tau, Aβ plaques, NFT.

Affiliation:

College of Physical Science and Technology, Zhengzhou University, Zhengzhou 450001, Beijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, College of Physical Science and Technology, Zhengzhou University, Zhengzhou 450001, Department of Nuclear Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing 100071, College of Physical Science and Technology, Zhengzhou University, Zhengzhou 450001, Beijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, College of Physical Science and Technology, Zhengzhou University, Zhengzhou 450001, College of Physical Science and Technology, Zhengzhou University, Zhengzhou 450001, College of Physical Science and Technology, Zhengzhou University, Zhengzhou 450001, College of Physical Science and Technology, Zhengzhou University, Zhengzhou 450001, Beijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, Beijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, Beijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, Beijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, National-Local Joint Engineering Research Center of Rehabilitation Medicine Technology, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, Department of Nuclear Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing 100071, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100071



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