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A Qualitative Analysis Based on Relative Expression Orderings Identifies Transcriptional Subgroups for Alzheimer’s Disease

[ Vol. 16 , Issue. 13 ]

Author(s):

Guini Hong, Pengming Zeng, Na Li, Hao Cai, You Guo, Xiaopeng Li, Keshen Li* and Hongdong Li*   Pages 1175 - 1182 ( 8 )

Abstract:


Background: Alzheimer's disease (AD) is a heterogeneous neurodegenerative disease. However, few studies have investigated the heterogeneous gene expression patterns in AD.

Objective and Methods: We examined the gene expression patterns in four brain regions of AD based on the within-sample relative expression orderings (REOs). Gene pairs with significantly reversed REOs in AD samples compared to non-AD controls were identified for each brain region using Fisher’s exact test, and filtered according to their transcriptional differences between AD samples. Subgroups of AD were classified by cluster analysis.

Results: REO-based gene expression profiling analyses revealed that transcriptional differences, as well as distinct disease subsets, existed within AD patients. For each brain region, two main subgroups were classified: one subgroup reported differentially expressed genes overlapped with the age-related genes, and the other was related to neuroinflammation.

Conclusion: AD transcriptional subgroups might help understand the underlying pathogenesis of AD, and lend support to a personalized approach to AD management.

Keywords:

Alzheimer’s Disease, relative expression orderings, aging, gene expression, transcriptional subgroups, neuroinflammation.

Affiliation:

College of Information Engineering, Gannan Medical University, Ganzhou 341000, Department of Bioinformatics, Fujian Medical University, Fuzhou, 350108, College of Information Engineering, Gannan Medical University, Ganzhou 341000, Medical Big Data and Bioinformatics Research Centre at First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, Medical Big Data and Bioinformatics Research Centre at First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, College of Information Engineering, Gannan Medical University, Ganzhou 341000, Department of Neurology and Stroke Center, The First Affiliated Hospital, Jinan University, Guangzhou, College of Information Engineering, Gannan Medical University, Ganzhou 341000



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