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Role of Cdk5 in Amyloid-beta Pathology of Alzheimer’s Disease

[ Vol. 16 , Issue. 13 ]

Author(s):

Tao-Tao Lu, Chengqun Wan, Wenming Yang* and Zhiyou Cai*   Pages 1206 - 1215 ( 10 )

Abstract:


Alzheimer’s Disease (AD) is a progressive neurodegenerative disease with irreversible cognitive impairment. So far, successful treatment and prevention for this disease are deficient in spite of delaying the progression of cognitive impairment and dementia. Cyclin dependent kinase 5 (Cdk5), a unique member of the cyclin-dependent kinase family, is involved in AD pathogenesis and may be a pathophysiological mediator that links the major pathological features of AD. Cdk5 dysregulation interferes with the proteolytic processing of Amyloid-beta Protein Precursor (APP) and modulates amyloidbeta (Aβ) by affecting three enzymes called α-, β- and γ-secretase, which are critical for the hydrolysis of APP. Given that the accumulation and deposition of Aβ derived from APP are a common hinge point in the numerous pathogenic hypotheses of AD, figuring out that influence of specific mechanisms of Cdk5 on Aβ pathology will deepen our understanding of AD.

Keywords:

Cyclin dependent kinase 5, amyloid-beta, amyloid-beta protein precursor, Alzheimer’s disease.

Affiliation:

Department of Neurology, Chongqing General Hospital, University of Chinese Academy of Sciences, 400013, Chongqing, Department of Neurology, Chongqing General Hospital, University of Chinese Academy of Sciences, 400013, Chongqing, Departmentof Neurology, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, 230031 Anhui Province, Department of Neurology, Chongqing General Hospital, University of Chinese Academy of Sciences, 400013, Chongqing



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