Touqeer Ahmed*, Sana Javed, Ameema Tariq, Barbara Budzyńska, Grazia D’Onofrio, Maria Daglia, Seyed Fazel Nabavi and Seyed Mohammad Nabavi* Pages 365 - 375 ( 11 )
Among naturally occurring isoflavones, soy isoflavones are an important class with various biological activities. Due to their phytoestrogenic structure, their effects on the brain are profound thus making the neurobiological effects of these compounds an active area of research. One such compound is daidzein, which has been reported to affect various neurobiological regulatory mechanisms such as behavior, cognition, growth, development and reproduction. These effects are mainly elicited through the interaction of daidzein with different signaling molecules and receptors, thereby offering neuroprotection. In addition, daidzein has also been reported to possess activities against various neuropathological conditions mainly by its interaction with the cerebrovascular system. This review focuses on providing a comprehensive account on the bioavailability and metabolism of daidzein in vivo, and discusses its activities and mechanisms of action in detail, in both physiological and pathological conditions. In addition, the effects of daidzein on other disorders have also been examined briefly in this article.
Daidzein, genistein, hormones, neuroprotection, cellular pathways.
Neurobiology Laboratory, Atta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, Sector H-12, Islamabad - 44000, Neurobiology Laboratory, Department of Healthcare Biotechnology, Atta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, Sector H-12, Islamabad – 44000, Neurobiology Laboratory, Department of Healthcare Biotechnology, Atta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, Sector H-12, Islamabad – 44000, Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, 4a Chodzki Str., 20- 093 Lublin,, Geriatric Unit & Laboratory of Gerontology and Geriatrics, Department of Medical Sciences, IRCCS , Department of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, Pavia University, Via Taramelli 12, 27100 Pavia, Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, P.O. Box 19395-5487