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Towards Retinoid Therapy for Alzheimers Disease

[ Vol. 6 , Issue. 3 ]

Author(s):

K. Shudo, H. Fukasawa, M. Nakagomi and N. Yamagata   Pages 302 - 311 ( 10 )

Abstract:


Alzheimers disease(AD) is associated with a variety of pathophysiological features, including amyloid plaques, inflammation, immunological changes, cell death and regeneration processes, altered neurotransmission, and agerelated changes. Retinoic acid receptors (RARs) and retinoids are relevant to all of these. Here we review the pathology, pharmacology, and biochemistry of AD in relation to RARs and retinoids, and we suggest that retinoids are candidate drugs for treatment of AD.

Keywords:

Alzheimer's disease, retinoid, retinoic acid receptors, inflammation, immunology, regulatory T cell, neurodegeneration

Affiliation:

Research Foundation ITSUU Laboratory, 2-28-10 tamagawa, setagaya-ku, Tokyo 158-0094, Japan.



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