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A Neurotrophic Rationale for the Therapy of Neurodegenerative Disorders

[ Vol. 6 , Issue. 5 ]


H. Uri Saragovi, Edith Hamel and Adriana Di Polo   Pages 419 - 423 ( 5 )


The concept and rationale for neuroprotection are presented. Several examples of small molecule neurotrophic agents with favourable drug-like and pharmacological properties are shown. Compound efficacy in acute neurodegenerative models (optic nerve axotomy) and chronic neurodegenerative models (glaucoma, age-associated cognitive impairment, Alzheimers Disease) are evaluated and discussed. Targeting neurotrophin receptors with ligands that activate survival pathways or inhibit death pathways is an alternative worth pursuing.

, A, Neurotrophic, Rationale, for, the, Therapy, of, Neurodegenerative, Disorders


Lady Davis Institute-Jewish General Hospital, 3755 Cote St. Catherine. E-535, Montreal, Quebec–Canada H3T 1E2.

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