H. Uri Saragovi, Edith Hamel and Adriana Di Polo Pages 419 - 423 ( 5 )
The concept and rationale for neuroprotection are presented. Several examples of small molecule neurotrophic agents with favourable drug-like and pharmacological properties are shown. Compound efficacy in acute neurodegenerative models (optic nerve axotomy) and chronic neurodegenerative models (glaucoma, age-associated cognitive impairment, Alzheimers Disease) are evaluated and discussed. Targeting neurotrophin receptors with ligands that activate survival pathways or inhibit death pathways is an alternative worth pursuing., A, Neurotrophic, Rationale, for, the, Therapy, of, Neurodegenerative, Disorders
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