Submit Manuscript  

Article Details


O-GlcNAc Modification and the Tauopathies: Insights from Chemical Biology

[ Vol. 6 , Issue. 5 ]

Author(s):

Scott A. Yuzwa and David J. Vocadlo   Pages 451 - 454 ( 4 )

Abstract:


The aggregation of the microtubule-associated protein tau into paired-helical filaments is the defining characteristic of the tauopathies. It has become apparent that the hyperphosphorylation of tau likely plays a role in the aggregation process and thus strategies to reduce tau phosphorylation are generating wide interest. The O-GlcNAc posttranslational modification of tau has been shown to be reciprocal to its phosphorylation; increasing O-GlcNAc leads to reductions in tau phosphorylation. In this mini-review, we highlight the use of chemical compounds as a means of understanding the reciprocal nature of tau phosphorylation and tau O-GlcNAcylation and highlight some recent progress in this area.

Keywords:

Tau, O-GlcNAc, phosphorylation, glucosaminidase, glycoside hydrolase

Affiliation:

Department of Molecular Biology and Biochemistry and Department of Chemistry, Simon Fraser University, 8888 University Dr, Burnaby, BC, V5A 1S6, Canada.



Read Full-Text article