Review Article

Research Progress in Reversal of Tumor Multi-drug Resistance via Natural Products

Author(s):

Qi Guo, Hongyan Cao, Xianghui Qi, Huikai Li, Peizhi Ye, Zhiguo Wang, Danqiao Wang and Mingyu Sun*   Pages 1466 - 1476 ( 11 )

Abstract:

Multidrug resistance occurs when a tumor develops resistance to multiple chemotherapeutic drugs, which may include antitumor drugs with different chemical structures and mechanisms. Multidrug resistance limits the treatment effects of antitumor drugs, and is the main cause of chemotherapy failure. Multidrug resistance is caused by numerous factors including changes in ATP-binding cassette transporters, target proteins, detoxification, deoxyribonucleic acid repair, drug metabolic enzymes, and signal pathways of apoptosis. Clinical research indicates that natural products have great potential to treat tumors and reverse multidrug resistance. Natural products, which often have multiple targets, could play an important role in tumor treatment, have beneficial effects on tumor inhibition, improve symptoms, reduce radiotherapy and chemotherapy side effects, enhance immunity, and prolong survival. Because natural products often have few adverse reactions and less drug resistance, the antitumor activities of natural products have attracted extensive research. We aimed to review the basic research and clinical application of natural products in the reversal of multidrug resistance.

Keywords:

Chemotherapeutics, MDR, multi-drug resistance, natural products, tumor, drug.

Affiliation:

School of Medicine, University of Jiangsu, Zhenjiang, Key Laboratory of Liver and Kidney Diseases, Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, School of Medicine, University of Jiangsu, Zhenjiang, Tianjin Medical University Cancer Institute & Hospital, Tianjin, Cancer Institute & Hospital, Chinese Academy of Medical Sciences, Beijing, Experimental Research Center, Academy of Chinese Medical Sciences, Beijing, Experimental Research Center, Academy of Chinese Medical Sciences, Beijing, Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, 528 Zhangheng Road, Pudong New District, Shanghai 201203

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