Shuangshuang Zhang, Yong Wang, Jinsong Cheng, Ning Huangfu, Ruochi Zhao, Zhenyu Xu, Fuxing Zhang, Wenyuan Zheng and Dandan Zhang* Pages 700 - 709 ( 10 )
Purine metabolism in the circulatory system yields uric acid as its final oxidation product, which is believed to be linked to the development of gout and kidney stones. Hyperuricemia is closely correlated with cardiovascular disease, metabolic syndrome, and chronic kidney disease, as attested by the epidemiological and empirical research. In this review, we summarize the recent knowledge about hyperuricemia, with a special focus on its physiology, epidemiology, and correlation with cardiovascular disease. This review also discusses the possible positive effects of treatment to reduce urate levels in patients with cardiovascular disease and hyperuricemia, which may lead to an improved clinical treatment plan.
Uric acid, hyperuricaemia, cardiovascular diseases, gout, metabolic syndrome, chronic kidney disease.
Department of Cardiovascular Medicine, Ningbo First Hospital, Ningbo, Zhejiang 315000, Department of Cardiovascular Medicine, Ningbo First Hospital, Ningbo, Zhejiang 315000, Department of Cardiovascular Medicine, Ningbo First Hospital, Ningbo, Zhejiang 315000, Department of Cardiovascular Medicine, Ningbo First Hospital, Ningbo, Zhejiang 315000, Department of Cardiovascular Medicine, Ningbo First Hospital, Ningbo, Zhejiang 315000, Department of Cardiovascular Medicine, Ningbo First Hospital, Ningbo, Zhejiang 315000, Department of Cardiovascular Medicine, Ningbo First Hospital, Ningbo, Zhejiang 315000, Department of Cardiovascular Medicine, Ningbo First Hospital, Ningbo, Zhejiang 315000, Department of Pharmacy, The Affiliated Hospital of Medical School of Ningbo University, Ningbo, Zhejiang