Mini-Review Article

Fine Tuning of Intracellular Ca²⁺ Content by Pharmacological Agents – A Strategy to Prevent Synapse Loss in Alzheimer Disease Hippocampal Neurons

Author(s):

Elena Popugaeva*   Pages 1065 - 1071 ( 7 )

Abstract:

<p>Alzheimer disease is the dominant form of elderly dementia. Today all clinical trials that target &#946;-amyloid have failed to indicate that &#946;-amyloid may not be a causative agent in AD pathogenesis. Thus there is a need to search for alternative ways to treat AD patients. </P><P> Neuronal store-operated calcium entry is a fine-tuning mechanism that regulates intracellular Ca²⁺ content. Recent evidence suggests that store-operated calcium channels may be targeted with pharmacological agents in order to prevent synapse loss, recover long-term potentiation and change behavior. </P><P> Current mini-review discusses basic chemical structures that modulate intracellular calcium dysbalance via targeting store-operated calcium channels and their applicability as anti-AD pharmacological agents.</p>

Keywords:

Alzheimer&#39;s disease, calcium hypothesis, nSOCE, pharmacological agents, &#946;-amyloid, pharmacological.

Affiliation:

Laboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg Polytechnic University, St. Petersburg

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