Wen Shao, Xuwen He, Xin Li, Wuhai Tao, Junying Zhang, Shujuan Zhang, Lei Wang, Yanan Qiao, Yu Wang, Zhanjun Zhang* and Dantao Peng* Pages 35 - 44 ( 10 )
<p>Background and Objective: Subjective memory impairment (SMI) is a preclinical stage prior to amnestic mild cognitive impairment (aMCI) along with the Alzheimer’s disease (AD) continuum. We hypothesized that SMI patients had white matter (WM) network disruptions similar to those in aMCI patients. </P><P> Methods: We used diffusion-tensor magnetic resonance imaging and graph theory to construct, analyze, and compare the WM networks among 20 normal controls (NC), 20 SMI patients, and 20 aMCI patients. </P><P> Results: Compared with the NC group, the SMI group had significantly decreased global and local efficiency and an increased shortest path length. Moreover, similar to the aMCI group, the SMI group had lower nodal efficiency in regions located in the frontal and parietal lobes, limbic systems, and caudate nucleus compared to that of the NC group. </P><P> Conclusion: Similar to aMCI patient, SMI patients exhibited WM network disruptions, and detection of these disruptions could facilitate the early detection of SMI.</p>
Subjective memory impairment, Alzheimer's disease, mild cognitive impairment, amnestic mild cognitive impairment, white matter, network.
Department of Neurology, China-Japan Friendship Hospital, Beijing 100029, State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, Department of Neurology, China-Japan Friendship Hospital, Beijing 100029, Department of Neurology, China-Japan Friendship Hospital, Beijing 100029, Department of Neurology, China-Japan Friendship Hospital, Beijing 100029, Department of Neurology, China-Japan Friendship Hospital, Beijing 100029, State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, Department of Neurology, China-Japan Friendship Hospital, Beijing 100029