Soo-Hyun Cho, Hak Y. Rhee, Janghoon Oh, Jin S. Lee, Soonchan Park, Won C. Shin, Jong-Woo Paik, Chang-Woo Ryu, Key C. Park and Geon-Ho Jahng* Pages 335 - 346 ( 12 )
<P>Background: Longitudinal changes of brain metabolites during a functional stimulation are unknown in amnestic mild cognitive impairment (aMCI) and Alzheimer’s disease (AD) subjects. </P><P> Objective: This study was to evaluate the longitudinal changes of brain metabolites using proton magnetic resonance spectroscopy (1H MRS) in response to treatment during a memory task in the subjects of cognitive normal (CN), aMCI, and AD. </P><P> Methods: We acquired functional magnetic resonance spectroscopy (fMRS) data from 28 CN elderly, 16 aMCI and 12 AD subjects during a face-name association task. We measured fMRS metabolite ratios over 24 months in the 8-month apart, determined the temporal changes of the metabolites, and evaluated the differences among the three groups under the three different conditions (base, novel, repeat). </P><P> Results: The results of comparisons for the three subject groups and the three-time points showed that tNAA/tCho and tCr/tCho were statistically significant among the three subject groups in any of the three conditions. The dynamic temporal change measurements for the metabolites for each condition showed that Glx/tCho and Glu/tCho levels at the third visit increased significantly compared with in the first visit in the novel condition in the AD group. </P><P> Conclusion: We found declines in tNAA/tCho and tCr/tCho in the aMCI and AD subjects with increasing disease severity, being highest in CN and lowest in AD. The Glx/tCho level increased temporally in the AD subjects after they took an acetylcholine esterase inhibitor. Therefore, Glx may be suitable to demonstrate functional recovery after treatment.</P>
Longitudinal study, functional magnetic resonance spectroscopy, Alzheimer's disease, mild cognitive impairment, glutamine and glutamate complex (Glx), total N-acetylaspartate (tNAA).
Department of Neurology, Chonnam National University Hospital, Chonnam National University Medical School, #42 Jebong-ro, Dong-gu, Gwangju, 61469, Department of Neurology, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, #892 Dongnam-ro, Gangdong-gu, Seoul, 05278, Department of Biomedical Science and Technology, Graduate School, Kyung Hee University, #26 Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, Department of Neurology, Kyung Hee University Hospital, College of Medicine, Kyung Hee University, #23 Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, Department of Radiology, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, #892 Dongnam-ro, Gangdong-gu, Seoul, 05278, Department of Neurology, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, #892 Dongnam-ro, Gangdong-gu, Seoul, 05278, Department of Psychiatry, Kyung Hee University Hospital, College of Medicine, Kyung Hee University, #23 Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, Department of Radiology, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, #892 Dongnam-ro, Gangdong-gu, Seoul, 05278, Department of Neurology, Kyung Hee University Hospital, College of Medicine, Kyung Hee University, #23 Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, Department of Radiology, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, #892 Dongnam-ro, Gangdong-gu, Seoul, 05278