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Neural and Retinal Characteristics in Relation to Working Memory in Older Adults with Mild Cognitive Impairment

[ Vol. 18 , Issue. 3 ]


Mabel N.K. Wong, Daniel W.L. Lai, Henry H.-L. Chan and Bess Y.-H. Lam*   Pages 185 - 195 ( 11 )


Objective: This study investigated the relationship between neural activities and retinal structures associated with working memory (WM) in older adults with mild cognitive impairment (MCI).

Methods: Eleven older adults with MCI and 29 healthy controls (60 to 73 years old) were tested. All participants underwent an event-related potential (ERP) recording while performing the two-back memory task. The Optical coherence tomography angiography (OCT-A) was administered to examine the perfusion and vessel density in the retina.

Results: Results showed that WM performance in the MCI group was negatively associated with ERP latencies in central parietal regions (CP6 and CP8) (ps< 0.05). The left nasal vessel and perfusion densities were negatively correlated with the latencies in these two central parietal regions and positively related to WM performance only in the MCI group (ps< 0.05).

Conclusion: The findings on WM, central parietal brain activity, and left nasal vessel and perfusion densities in the retina help us gain a better understanding of the neural and retinal underpinnings of WM in relation to MCI.


Mild cognitive impairment, retinal perfusion density, retinal vessel density, working memory, event-related potential, cognition.


Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, 11 Yuk Choi Rd, Hung Hom, Department of Social Work, The Hong Kong Baptist University, 224 Waterloo Rd, Kowloon Tong, School of Optometry, The Hong Kong Polytechnic University, 11 Yuk Choi Rd, Hung Hom, Department of Psychiatry, The University of Hong Kong, Pok Fu Lam

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