Article Details
Biological Potential of Halfsandwich Ruthenium(II) and Iridium (III) Complexes
Author(s):
Gerd Ludwig, Marija Mojić, Mirna Bulatović, Sanja Mijatović, Danijela Maksimović-Ivanić, Dirk Steinborn and Goran N. Kaluđerović Pages 1455 - 1460 ( 6 )
Abstract:
In vitro studies with the ruthenium(II) and analogous iridium(III) complexes [Ru(η6- p-cymene)Cl<sub>2</sub>{Ph<sub>2</sub>PCH<sub>2</sub>CH<sub>2</sub>CH<sub>2</sub>S(O)<sub>x</sub>Ph-κP}], [Ru(η6-p-cymene)Cl{Ph2PCH2CH2CH2S(O)<sub>x</sub>Ph- κP,κS}][PF<sub>6</sub>] (1–4), [Ir(η<sup>5</sup>-C<sub>5</sub>Me<sub>5</sub>)Cl2{Ph<sub>2</sub>PCH<sub>2</sub>CH<sub>2</sub>CH2S(O)<sub>x</sub>Ph-κP}] and [Ir(η5-C5Me5)Cl{Ph2 PCH<sub>2</sub>CH<sub>2</sub>CH<sub>2</sub>S(O)<sub>x</sub>Ph-κP,κS}][PF<sub>6</sub>] (5–8; x = 0, 1) revealed the high selectivity toward the 8505C, A253, MCF-7, SW480 and 518A2 cancer cell lines. Thus, the cationic ruthenium complex 4 proved to be the most selective one. In case of the neutral and cationic ruthenium complexes 1–4 the caspase-dependent apoptotic cell death was proven as the main cause of the drug’s tumoricidal action on 8505C cell line.
Keywords:
Apoptosis, autophagy, caspase, cisplatin, iridium(III) complexes, ruthenium(II) complexes.
Affiliation:
, , , , , , Department of Bioorganic Chemistry, Leibniz-Institute of Plant Biochemistry, Weinberg 3, D 06120 Halle (Saale) Germany.
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